Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake.
Org Biomol Chem
; 13(13): 3856-62, 2015 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-25711305
The basic DNA recognition region of the GCN4 protein comprising 23 amino acids has been modified to contain two optimally positioned cysteines which have been linked and stapled using cross-linkers of suitable lengths. This results in stapled peptides with a stabilized α-helical conformation which allows for DNA binding and concurrent enhancement of cellular uptake.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
ADN
/
Proteínas de Saccharomyces cerevisiae
/
Factores de Transcripción con Cremalleras de Leucina de Carácter Básico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Bélgica