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Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study.
Melichar, Bohuslav; Adenis, Antoine; Lockhart, A Craig; Bennouna, Jaafar; Dees, E Claire; Kayaleh, Omar; Obermannova, Radka; DeMichele, Angela; Zatloukal, Petr; Zhang, Bin; Ullmann, Claudio Dansky; Schusterbauer, Claudia.
Afiliación
  • Melichar B; Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic. Electronic address: bohuslav.melichar@fnol.cz.
  • Adenis A; Centre Oscar Lambret, Lille, France.
  • Lockhart AC; Washington University School of Medicine, St Louis, MO, USA.
  • Bennouna J; Institut de Cancérologie de l'Ouest, Nantes, France.
  • Dees EC; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
  • Kayaleh O; Department of Internal Medicine, MD Anderson Cancer Center, Orlando, FL, USA.
  • Obermannova R; Department of Pharmacology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
  • DeMichele A; Abramson Cancer Center, Philadelphia, PA, USA.
  • Zatloukal P; Department of Pneumology and Thoracic Surgery, Charles University, Prague, Czech Republic.
  • Zhang B; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA.
  • Ullmann CD; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA.
  • Schusterbauer C; Millennium Pharmaceuticals, Inc, Cambridge, MA, USA.
Lancet Oncol ; 16(4): 395-405, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25728526
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Azepinas / Neoplasias de la Mama / Neoplasias Esofágicas / Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias de Cabeza y Cuello Tipo de estudio: Guideline Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Azepinas / Neoplasias de la Mama / Neoplasias Esofágicas / Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias de Cabeza y Cuello Tipo de estudio: Guideline Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article