Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother
; 59(5): 2960-3, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25753637
ABSTRACT
The role of mecA mutations in conferring resistance to ceftobiprole and ceftaroline, cephalosporins with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, was determined with MRSA strains COL and SF8300. The SF8300 ceftaroline-passaged mutant carried a single mecA mutation, E447K (E-to-K change at position 447), and expressed low-level resistance. This mutation in COL conferred high-level resistance to ceftobiprole but only low-level resistance to ceftaroline. The COL ceftaroline-passaged mutant, which expressed high-level resistance to ceftobiprole and ceftaroline, had mutations in pbp2, pbp4, and gdpP but not mecA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cefalosporinas
/
Staphylococcus aureus Resistente a Meticilina
/
Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos