Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.

Meng, Xiangbing; Yang, Shujie; Zhang, Yuping; Wang, Xinjun; Goodfellow, Renee X; Jia, Yichen; Thiel, Kristina W; Reyes, Henry D; Yang, Baoli; Leslie, Kimberly K

Meng, Xiangbing; Yang, Shujie; Zhang, Yuping; Wang, Xinjun; Goodfellow, Renee X; Jia, Yichen; Thiel, Kristina W; Reyes, Henry D; Yang, Baoli; Leslie, Kimberly K.

Afiliación

Meng X; From the Department of Obstetrics and Gynecology and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242 xiangbing-meng@uiowa.edu.
Yang S; From the Department of Obstetrics and Gynecology and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242.
Zhang Y; From the Department of Obstetrics and Gynecology and.
Wang X; From the Department of Obstetrics and Gynecology and.
Goodfellow RX; From the Department of Obstetrics and Gynecology and.
Jia Y; From the Department of Obstetrics and Gynecology and.
Thiel KW; From the Department of Obstetrics and Gynecology and.
Reyes HD; From the Department of Obstetrics and Gynecology and.
Yang B; From the Department of Obstetrics and Gynecology and.
Leslie KK; From the Department of Obstetrics and Gynecology and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242.

J Biol Chem ; 290(19): 11853-64, 2015 May 08.

Article en En | MEDLINE | ID: mdl-25787082

Asunto(s)

Regulación de la Expresión Génica; Infertilidad Masculina/genética; Proteínas de la Membrana/genética; Proteínas de la Membrana/fisiología; ARN Pequeño no Traducido/metabolismo; Espermatogénesis/genética; Animales; Daño del ADN; Reparación del ADN; Exones; Eliminación de Gen; Genotipo; Homocigoto; Hibridación Fluorescente in Situ; Masculino; Ratones; Ratones Noqueados; MicroARNs/metabolismo; Proteínas de Unión al ARN; Espermatocitos/metabolismo; Espermatozoides/fisiología; Testículo/metabolismo

Palabras clave

AEG-1; DNA Damage; Development; MTDH; Male Infertility; Meiosis; MicroRNA (miRNA); Mili; Pachytene; Rad18; Reproduction; Spermatogenesis; piRNA

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Espermatogénesis / Regulación de la Expresión Génica / ARN Pequeño no Traducido / Infertilidad Masculina / Proteínas de la Membrana Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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