Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.

LeMaster, David M; Mustafi, Sourajit M; Brecher, Matthew; Zhang, Jing; Héroux, Annie; Li, Hongmin; Hernández, Griselda

LeMaster, David M; Mustafi, Sourajit M; Brecher, Matthew; Zhang, Jing; Héroux, Annie; Li, Hongmin; Hernández, Griselda.

Afiliación

LeMaster DM; Wadsworth Center, New York State Department of Health, Albany, New York 12201; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York 12201.
Mustafi SM; Wadsworth Center, New York State Department of Health, Albany, New York 12201.
Brecher M; Wadsworth Center, New York State Department of Health, Albany, New York 12201.
Zhang J; Wadsworth Center, New York State Department of Health, Albany, New York 12201.
Héroux A; Brookhaven National Laboratory, Upton, New York 11973-5000.
Li H; Wadsworth Center, New York State Department of Health, Albany, New York 12201; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York 12201.
Hernández G; Wadsworth Center, New York State Department of Health, Albany, New York 12201; Department of Biomedical Sciences, School of Public Health, University at Albany, SUNY, Albany, New York 12201. Electronic address: griselda.hernandez@health.ny.gov.

J Biol Chem ; 290(25): 15746-15757, 2015 Jun 19.

Article en En | MEDLINE | ID: mdl-25953903

Asunto(s)

Modelos Moleculares; Receptores Androgénicos/química; Receptores de Glucocorticoides/química; Proteínas de Unión a Tacrolimus/química; Sustitución de Aminoácidos; Humanos; Mutación Missense; Resonancia Magnética Nuclear Biomolecular; Estructura Cuaternaria de Proteína; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Receptores Androgénicos/genética; Receptores Androgénicos/metabolismo; Receptores de Glucocorticoides/genética; Receptores de Glucocorticoides/metabolismo; Proteínas de Unión a Tacrolimus/genética; Proteínas de Unión a Tacrolimus/metabolismo

Palabras clave

allosteric regulation; conformational change; nuclear magnetic resonance (NMR); prolyl isomerase; x-ray crystallography

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Modelos Moleculares / Receptores Androgénicos / Receptores de Glucocorticoides / Proteínas de Unión a Tacrolimus Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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