Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NF&#954;B Signaling Pathway.

Landais, Igor; Pelton, Chantel; Streblow, Daniel; DeFilippis, Victor; McWeeney, Shannon; Nelson, Jay A

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.

Landais, Igor; Pelton, Chantel; Streblow, Daniel; DeFilippis, Victor; McWeeney, Shannon; Nelson, Jay A.

Afiliación

Landais I; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.
Pelton C; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.
Streblow D; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.
DeFilippis V; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.
McWeeney S; Division of Biostatistics, Public Health and Preventive Medicine, Oregon Health and Science University, Portland, Oregon, United States of America.
Nelson JA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America.

PLoS Pathog ; 11(5): e1004881, 2015 May.

Article en En | MEDLINE | ID: mdl-25955717

Asunto(s)

Citomegalovirus/metabolismo; Quinasas Asociadas a Receptores de Interleucina-1/metabolismo; MicroARNs/metabolismo; Interferencia de ARN; ARN Viral/metabolismo; Transducción de Señal; Receptor Toll-Like 2/antagonistas & inhibidores; Regiones no Traducidas 3'; Células Cultivadas; Fibroblastos/citología; Fibroblastos/inmunología; Fibroblastos/metabolismo; Genes Reporteros; Células HEK293; Humanos; Inmunidad Innata; Quinasas Asociadas a Receptores de Interleucina-1/genética; Ligandos; MicroARNs/genética; Monocitos/citología; Monocitos/inmunología; Monocitos/metabolismo; Mutación; FN-kappa B/genética; FN-kappa B/metabolismo; ARN Interferente Pequeño; ARN Viral/genética; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Receptor Toll-Like 2/genética; Receptor Toll-Like 2/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ARN Viral / Transducción de Señal / Citomegalovirus / MicroARNs / Interferencia de ARN / Receptor Toll-Like 2 / Quinasas Asociadas a Receptores de Interleucina-1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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