Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90ß as a Novel Mechanism of Rifampin-induced MDR1 Expression.

Kim, So Won; Hasanuzzaman, Md; Cho, Munju; Heo, Ye Rang; Ryu, Min-Jung; Ha, Na-Young; Park, Hyun June; Park, Hyung-Yeon; Shin, Jae-Gook

Kim, So Won; Hasanuzzaman, Md; Cho, Munju; Heo, Ye Rang; Ryu, Min-Jung; Ha, Na-Young; Park, Hyun June; Park, Hyung-Yeon; Shin, Jae-Gook.

Afiliación

Kim SW; From the Department of Pharmacology and the Institute for Clinical and Translational Research, Catholic Kwandong University College of Medicine, Gangneung 210-701, Korea, the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea, t
Hasanuzzaman M; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea.
Cho M; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea.
Heo YR; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea.
Ryu MJ; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea.
Ha NY; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea.
Park HJ; the Bio-MAX Institute, Seoul National University, Seoul 151-742, Korea, and.
Park HY; the Agriculture and Biotechnology Department, Noroo Holdings Co. Ltd., Seoul 135-983, Korea.
Shin JG; the Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Korea, the Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan 614-735, Korea, phshinjg@gmail.com.

J Biol Chem ; 290(27): 17029-40, 2015 Jul 03.

Article en En | MEDLINE | ID: mdl-25995454

Asunto(s)

Proteínas HSP90 de Choque Térmico/metabolismo; Rifampin/farmacología; Subfamilia B de Transportador de Casetes de Unión a ATP/genética; Subfamilia B de Transportador de Casetes de Unión a ATP/metabolismo; Secuencias de Aminoácidos; Quinasa de la Caseína II/química; Quinasa de la Caseína II/genética; Quinasa de la Caseína II/metabolismo; Línea Celular Tumoral; Regulación de la Expresión Génica/efectos de los fármacos; Proteínas HSP90 de Choque Térmico/química; Proteínas HSP90 de Choque Térmico/genética; Humanos; Simulación del Acoplamiento Molecular; Fosforilación/efectos de los fármacos; Receptor X de Pregnano; Receptores de Esteroides/genética; Receptores de Esteroides/metabolismo; Rifampin/química

Palabras clave

ABC transporter; casein kinase 2 (CK2); colorectal cancer; drug resistance; heat shock protein 90 (Hsp90); heat shock protein 90 ß (Hsp90ß); permeability glycoprotein (P-gp); pregnane X receptor (PXR); rifampin; tuberculosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rifampin / Proteínas HSP90 de Choque Térmico Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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