Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials.
Pediatr Radiol
; 45(11): 1600-15, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26045035
ABSTRACT
Cancer is the leading cause of death in children older than 1 year of age and new drugs are necessary to improve outcomes. Imaging is crucial to the drug development process and assessment of therapeutic response. In adults, tumours are often assessed with CT using size criteria. Unfortunately, techniques established in adults are not necessarily applicable in children due to differing pathophysiology, ability to cooperate and increased susceptibility to ionising radiation. MRI, in particular quantitative MRI, has to date not been fully utilised in children with extracranial neoplasms. The specific challenges of imaging in children, the potential for functional imaging techniques to inform upon and their inclusion in clinical trials are discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Tomografía Computarizada por Rayos X
/
Ensayos Clínicos como Asunto
/
Monitoreo de Drogas
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
/
Newborn
Idioma:
En
Revista:
Pediatr Radiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido