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CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency.
Smoum, Reem; Baraghithy, Saja; Chourasia, Mukesh; Breuer, Aviva; Mussai, Naama; Attar-Namdar, Malka; Kogan, Natalya M; Raphael, Bitya; Bolognini, Daniele; Cascio, Maria G; Marini, Pietro; Pertwee, Roger G; Shurki, Avital; Mechoulam, Raphael; Bab, Itai.
Afiliación
  • Smoum R; Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Baraghithy S; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Chourasia M; Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel; The Lise-Meitner Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Breuer A; Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Mussai N; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Attar-Namdar M; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Kogan NM; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Raphael B; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Bolognini D; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom; Molecular Pharmacology Group, Institute of Molecular, Cell and System Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
  • Cascio MG; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom;
  • Marini P; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom;
  • Pertwee RG; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom;
  • Shurki A; Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel; The Lise-Meitner Minerva Center for Computational Quantum Chemistry, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
  • Mechoulam R; Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 91120, Israel; raphaelm@ekmd.huji.ac.il.
  • Bab I; Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel;
Proc Natl Acad Sci U S A ; 112(28): 8774-9, 2015 Jul 14.
Article en En | MEDLINE | ID: mdl-26124120
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cannabinoides / Receptor Cannabinoide CB2 / Agonistas de Receptores de Cannabinoides Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cannabinoides / Receptor Cannabinoide CB2 / Agonistas de Receptores de Cannabinoides Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article