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The prodrug DHED selectively delivers 17ß-estradiol to the brain for treating estrogen-responsive disorders.
Prokai, Laszlo; Nguyen, Vien; Szarka, Szabolcs; Garg, Puja; Sabnis, Gauri; Bimonte-Nelson, Heather A; McLaughlin, Katie J; Talboom, Joshua S; Conrad, Cheryl D; Shughrue, Paul J; Gould, Todd D; Brodie, Angela; Merchenthaler, Istvan; Koulen, Peter; Prokai-Tatrai, Katalin.
Afiliación
  • Prokai L; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. AgyPharma LLC, Mansfield, TX 76063, USA. laszlo.prokai@unthsc.edu.
  • Nguyen V; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Szarka S; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Garg P; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. Vision Research Center and Departments of Ophthalmology and Basic Medical Science, University of Missouri-Kansas City, School of Medicine, Kansas City, MO 64108, USA.
  • Sabnis G; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Bimonte-Nelson HA; Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. Arizona Alzheimer's Consortium, Tempe, AZ 85014, USA.
  • McLaughlin KJ; Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
  • Talboom JS; Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. Arizona Alzheimer's Consortium, Tempe, AZ 85014, USA.
  • Conrad CD; Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
  • Shughrue PJ; Department of Pharmacology, Elan Pharmaceuticals Inc., South San Francisco, CA 94080, USA.
  • Gould TD; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Brodie A; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Merchenthaler I; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Koulen P; Vision Research Center and Departments of Ophthalmology and Basic Medical Science, University of Missouri-Kansas City, School of Medicine, Kansas City, MO 64108, USA.
  • Prokai-Tatrai K; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. AgyPharma LLC, Mansfield, TX 76063, USA.
Sci Transl Med ; 7(297): 297ra113, 2015 Jul 22.
Article en En | MEDLINE | ID: mdl-26203081
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Profármacos / Estradiol / Estrógenos / Androstenodioles Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Profármacos / Estradiol / Estrógenos / Androstenodioles Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos