Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity.

Yan, Fang; Liu, Johnson J; Ip, Virginia; Jamieson, Stephen M F; McKeage, Mark J

Yan, Fang; Liu, Johnson J; Ip, Virginia; Jamieson, Stephen M F; McKeage, Mark J.

Afiliación

Yan F; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Liu JJ; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Ip V; School of Medicine, Faculty of Health, University of Tasmania, Hobart, Tasmania, Australia.
Jamieson SM; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
McKeage MJ; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

J Neurochem ; 135(6): 1099-112, 2015 Dec.

Article en En | MEDLINE | ID: mdl-26364854

Asunto(s)

Daño del ADN/efectos de los fármacos; ADN/efectos de los fármacos; Quimioterapia; Neuronas/efectos de los fármacos; Síndromes de Neurotoxicidad/tratamiento farmacológico; Compuestos Organoplatinos/farmacología; Platino (Metal)/farmacología; Animales; Proteínas de Transporte de Catión/efectos de los fármacos; Proteínas de Transporte de Catión/metabolismo; Células Cultivadas; Ganglios Espinales/citología; Ganglios Espinales/efectos de los fármacos; Neuronas/metabolismo; Síndromes de Neurotoxicidad/metabolismo; Oxaliplatino; Ratas

Palabras clave

DNA damage; DRG neurons; anticancer drug toxicity; global transcription; neuronal atrophy; neurotoxicity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Platino (Metal) / Daño del ADN / ADN / Síndromes de Neurotoxicidad / Quimioterapia / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurochem Año: 2015 Tipo del documento: Article País de afiliación: Nueva Zelanda

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