IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.
Immunobiology
; 221(2): 291-9, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26547104
ABSTRACT
In a previous study, lack of IL-12 signaling in il12rb2 knock-out mice was found to predispose to lung adenocarcinoma (LAC). We asked whether specific polymorphisms of the human IL12RB2 gene may confer susceptibility to LAC. We studied IL12RB2 single nucleotide polymorphisms (SNPs) spanning from the promoter to the first untranslated exon of the gene. Genotypes of 49 individuals with LAC were compared with those of 93 healthy subjects. Two allele variants were found to be associated with increased susceptibility to LAC. One haplotype (hap), hap18, was more frequent in patients (18%) versus controls (6%) and significantly associated with increased probability of disease occurrence. Furthermore, IL-12 driven STAT4 phosphorylation in T cell blasts from healthy individuals was found to correlate with both single allele variants and haplotypes. In conclusion, genetically determined low signaling activity of IL-12R predisposes to the development of LAC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Receptores de Interleucina-12
/
Neoplasias Pulmonares
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Immunobiology
Año:
2016
Tipo del documento:
Article