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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.
Pennington, Lewis D; Bartberger, Michael D; Croghan, Michael D; Andrews, Kristin L; Ashton, Kate S; Bourbeau, Matthew P; Chen, Jie; Chmait, Samer; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Hong, Fang-Tsao; Hungate, Randall W; Jordan, Steven R; Kong, Ke; Liu, Longbin; Michelsen, Klaus; Moyer, Carolyn; Nishimura, Nobuko; Norman, Mark H; Reichelt, Andreas; Siegmund, Aaron C; Sivits, Glenn; Tadesse, Seifu; Tegley, Christopher M; Van, Gwyneth; Yang, Kevin C; Yao, Guomin; Zhang, Jiandong; Lloyd, David J; Hale, Clarence; St Jean, David J.
Afiliación
  • Pennington LD; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Bartberger MD; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Croghan MD; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Andrews KL; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Ashton KS; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Bourbeau MP; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Chen J; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Chmait S; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Cupples R; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Fotsch C; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Helmering J; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Hong FT; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Hungate RW; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Jordan SR; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Kong K; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Liu L; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Michelsen K; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Moyer C; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Nishimura N; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Norman MH; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Reichelt A; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Siegmund AC; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Sivits G; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Tadesse S; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Tegley CM; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Van G; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Yang KC; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Yao G; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Zhang J; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Lloyd DJ; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • Hale C; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
  • St Jean DJ; Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
J Med Chem ; 58(24): 9663-79, 2015 Dec 24.
Article en En | MEDLINE | ID: mdl-26551034
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Tiofenos / Proteínas Adaptadoras Transductoras de Señales / Glucoquinasa / Hipoglucemiantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Tiofenos / Proteínas Adaptadoras Transductoras de Señales / Glucoquinasa / Hipoglucemiantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos