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Genome-wide patterns of selection in 230 ancient Eurasians.
Mathieson, Iain; Lazaridis, Iosif; Rohland, Nadin; Mallick, Swapan; Patterson, Nick; Roodenberg, Songül Alpaslan; Harney, Eadaoin; Stewardson, Kristin; Fernandes, Daniel; Novak, Mario; Sirak, Kendra; Gamba, Cristina; Jones, Eppie R; Llamas, Bastien; Dryomov, Stanislav; Pickrell, Joseph; Arsuaga, Juan Luís; de Castro, José María Bermúdez; Carbonell, Eudald; Gerritsen, Fokke; Khokhlov, Aleksandr; Kuznetsov, Pavel; Lozano, Marina; Meller, Harald; Mochalov, Oleg; Moiseyev, Vyacheslav; Guerra, Manuel A Rojo; Roodenberg, Jacob; Vergès, Josep Maria; Krause, Johannes; Cooper, Alan; Alt, Kurt W; Brown, Dorcas; Anthony, David; Lalueza-Fox, Carles; Haak, Wolfgang; Pinhasi, Ron; Reich, David.
Afiliación
  • Mathieson I; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Lazaridis I; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Rohland N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Mallick S; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Patterson N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Roodenberg SA; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Harney E; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Stewardson K; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Fernandes D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Novak M; Independent researcher, Santpoort-Noord, The Netherlands.
  • Sirak K; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Gamba C; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Jones ER; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Llamas B; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Dryomov S; School of Archaeology and Earth Institute, Belfield, University College Dublin, Dublin 4, Ireland.
  • Pickrell J; School of Archaeology and Earth Institute, Belfield, University College Dublin, Dublin 4, Ireland.
  • Arsuaga JL; Institute for Anthropological Research, Zagreb 10000, Croatia.
  • de Castro JM; School of Archaeology and Earth Institute, Belfield, University College Dublin, Dublin 4, Ireland.
  • Carbonell E; Department of Anthropology, Emory University, Atlanta, Georgia 30322, USA.
  • Gerritsen F; School of Archaeology and Earth Institute, Belfield, University College Dublin, Dublin 4, Ireland.
  • Khokhlov A; Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
  • Kuznetsov P; Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
  • Lozano M; Australian Centre for Ancient DNA, School of Biological Sciences &Environment Institute, University of Adelaide, Adelaide, South Australia 5005, Australia.
  • Meller H; Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Mochalov O; Department of Paleolithic Archaeology, Institute of Archaeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Moiseyev V; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Guerra MA; Centro Mixto UCM-ISCIII de Evolución y Comportamiento Humanos, 28040 Madrid, Spain.
  • Roodenberg J; Departamento de Paleontología, Facultad Ciencias Geológicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Vergès JM; Centro Nacional de Investigacíon sobre Evolución Humana (CENIEH), 09002 Burgos, Spain.
  • Krause J; IPHES. Institut Català de Paleoecologia Humana i Evolució Social, Campus Sescelades-URV, 43007 Tarragona, Spain.
  • Cooper A; Area de Prehistoria, Universitat Rovira i Virgili (URV), 43002 Tarragona, Spain.
  • Alt KW; Netherlands Institute in Turkey, Istiklal Caddesi, Nur-i Ziya Sokak 5, Beyog˘ lu 34433, Istanbul, Turkey.
  • Brown D; Volga State Academy of Social Sciences and Humanities, Samara 443099, Russia.
  • Anthony D; Volga State Academy of Social Sciences and Humanities, Samara 443099, Russia.
  • Lalueza-Fox C; IPHES. Institut Català de Paleoecologia Humana i Evolució Social, Campus Sescelades-URV, 43007 Tarragona, Spain.
  • Haak W; Area de Prehistoria, Universitat Rovira i Virgili (URV), 43002 Tarragona, Spain.
  • Pinhasi R; State Office for Heritage Management and Archaeology Saxony-Anhalt and State Museum of Prehistory, D-06114 Halle, Germany.
  • Reich D; Volga State Academy of Social Sciences and Humanities, Samara 443099, Russia.
Nature ; 528(7583): 499-503, 2015 Dec 24.
Article en En | MEDLINE | ID: mdl-26595274
ABSTRACT
Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Selección Genética / Genoma Humano Tipo de estudio: Prognostic_studies Límite: Humans / Male País/Región como asunto: Asia / Europa Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Selección Genética / Genoma Humano Tipo de estudio: Prognostic_studies Límite: Humans / Male País/Región como asunto: Asia / Europa Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos