Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells.

Srdic-Rajic, Tatjana; Nikolic, Katarina; Cavic, Milena; Djokic, Ivana; Gemovic, Branislava; Perovic, Vladimir; Veljkovic, Nevena

Srdic-Rajic, Tatjana; Nikolic, Katarina; Cavic, Milena; Djokic, Ivana; Gemovic, Branislava; Perovic, Vladimir; Veljkovic, Nevena.

Afiliación

Srdic-Rajic T; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia.
Nikolic K; Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Serbia.
Cavic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia.
Djokic I; Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihaila Petrovica Alasa 14, 11001, Belgrade, Serbia.
Gemovic B; Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihaila Petrovica Alasa 14, 11001, Belgrade, Serbia.
Perovic V; Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihaila Petrovica Alasa 14, 11001, Belgrade, Serbia.
Veljkovic N; Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihaila Petrovica Alasa 14, 11001, Belgrade, Serbia. Electronic address: nevenav@vinca.rs.

Eur J Pharm Sci ; 81: 172-80, 2016 Jan 01.

Article en En | MEDLINE | ID: mdl-26598394

Asunto(s)

Antineoplásicos/farmacología; Receptores de Imidazolina/agonistas; Mitocondrias/efectos de los fármacos; Oxazoles/farmacología; Antibióticos Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Caspasa 3/genética; Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Ciclina B1/metabolismo; Doxorrubicina/farmacología; Humanos; Receptores de Imidazolina/metabolismo; Células K562; Leucemia/metabolismo; Mitocondrias/metabolismo; Proteínas Quinasas Activadas por Mitógenos/metabolismo; ARN Mensajero/metabolismo; Rilmenidina; Proteína X Asociada a bcl-2/genética

Palabras clave

Apoptosis; DNA damage; Imidazoline I1 receptor signaling; K562; Proliferation; Rilmenidine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxazoles / Receptores de Imidazolina / Mitocondrias / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article

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