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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aß isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Scannevin, Robert H; Chollate, Sowmya; Brennan, Melanie S; Snodgrass-Belt, Pamela A; Peng, Hairuo; Xu, Lin; Jung, Mi-Young; Bussiere, Thierry; Arastu, Mahin F; Talreja, Tina; Xin, Zhili; Dunstan, Robert W; Fahrer, Diana; Rohde, Ellen; Dunah, Anthone W; Wang, Joy; Kumaravel, Gnanasambandam; Taveras, Arthur G; Moore Arnold, H; Rhodes, Kenneth J.
Afiliación
  • Scannevin RH; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA. Electronic address: robert.scannevin@biogen.com.
  • Chollate S; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Brennan MS; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Snodgrass-Belt PA; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Peng H; Medicinal Chemistry, Biogen Inc., Cambridge, MA 02142, USA.
  • Xu L; Drug Metabolism and Pharmacokinetics, Biogen Inc., Cambridge, MA 02142, USA.
  • Jung MY; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Bussiere T; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Arastu MF; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Talreja T; Medicinal Chemistry, Biogen Inc., Cambridge, MA 02142, USA.
  • Xin Z; Medicinal Chemistry, Biogen Inc., Cambridge, MA 02142, USA.
  • Dunstan RW; Pathology, Biogen Inc., Cambridge, MA 02142, USA.
  • Fahrer D; Pathology, Biogen Inc., Cambridge, MA 02142, USA.
  • Rohde E; Drug Metabolism and Pharmacokinetics, Biogen Inc., Cambridge, MA 02142, USA.
  • Dunah AW; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Wang J; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Kumaravel G; Medicinal Chemistry, Biogen Inc., Cambridge, MA 02142, USA.
  • Taveras AG; Medicinal Chemistry, Biogen Inc., Cambridge, MA 02142, USA.
  • Moore Arnold H; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
  • Rhodes KJ; Neurology Research, Biogen Inc., Cambridge, MA 02142, USA.
Neuropharmacology ; 103: 57-68, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26690893
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Péptidos beta-Amiloides / Aldehídos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Péptidos beta-Amiloides / Aldehídos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2016 Tipo del documento: Article