Your browser doesn't support javascript.
loading
Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.
Ishizuka, Isabel E; Chea, Sylvestre; Gudjonson, Herman; Constantinides, Michael G; Dinner, Aaron R; Bendelac, Albert; Golub, Rachel.
Afiliación
  • Ishizuka IE; Committee on Immunology, University of Chicago, Chicago, Illinois, USA.
  • Chea S; Department of Pathology, University of Chicago, Chicago, Illinois, USA.
  • Gudjonson H; Institut Pasteur, Immunology Department, Lymphopoiesis Unit, Inserm U668, University Paris Diderot, Paris, France.
  • Constantinides MG; Committee on Immunology, University of Chicago, Chicago, Illinois, USA.
  • Dinner AR; Institute of Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA.
  • Bendelac A; Department of Chemistry, University of Chicago, Chicago, Illinois, USA.
  • Golub R; Committee on Immunology, University of Chicago, Chicago, Illinois, USA.
Nat Immunol ; 17(3): 269-76, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26779601
The precise lineage relationship between innate lymphoid cells (ILCs) and lymphoid tissue-inducer (LTi) cells is poorly understood. Using single-cell multiplex transcriptional analysis of 100 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common proximal precursor to these lineages and found that its bifurcation was marked by differential induction of the transcription factors PLZF and TCF1. Acquisition of individual effector programs specific to the ILC subsets ILC1, ILC2 and ILC3 was initiated later, at the common ILC precursor stage, by transient expression of mixed ILC1, ILC2 and ILC3 transcriptional patterns, whereas, in contrast, the development of LTi cells did not go through multilineage priming. Our findings provide insight into the divergent mechanisms of the differentiation of the ILC lineage and LTi cell lineage and establish a high-resolution 'blueprint' of their development.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos / Subgrupos Linfocitarios / Linfocitos T Colaboradores-Inductores / Linaje de la Célula Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos / Subgrupos Linfocitarios / Linfocitos T Colaboradores-Inductores / Linaje de la Célula Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos