Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus.
J Virol
; 90(7): 3794-9, 2016 Jan 20.
Article
en En
| MEDLINE
| ID: mdl-26792744
ABSTRACT
Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high affinity for α2,6-linked sialic acid receptor and acid and temperature stability. Thus, the hemagglutinin of the A/H7N9 virus may adopt traits associated with airborne transmission.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas Hemaglutininas del Virus de la Influenza
/
Sustitución de Aminoácidos
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Acoplamiento Viral
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Subtipo H7N9 del Virus de la Influenza A
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Países Bajos