Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-&#954;B in hepatocellular carcinoma.

Tsang, Daisy P F; Wu, William K K; Kang, Wei; Lee, Ying-Ying; Wu, Feng; Yu, Zhuo; Xiong, Lei; Chan, Anthony W; Tong, Joanna H; Yang, Weiqin; Li, May S M; Lau, Suki S; Li, Xiangchun; Lee, Sau-Dan; Yang, Yihua; Lai, Paul B S; Yu, Dae-Yeul; Xu, Gang; Lo, Kwok-Wai; Chan, Matthew T V; Wang, Huating; Lee, Tin L; Yu, Jun; Wong, Nathalie; Yip, Kevin Y; To, Ka-Fai; Cheng, Alfred S L

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.

Tsang, Daisy P F; Wu, William K K; Kang, Wei; Lee, Ying-Ying; Wu, Feng; Yu, Zhuo; Xiong, Lei; Chan, Anthony W; Tong, Joanna H; Yang, Weiqin; Li, May S M; Lau, Suki S; Li, Xiangchun; Lee, Sau-Dan; Yang, Yihua; Lai, Paul B S; Yu, Dae-Yeul; Xu, Gang; Lo, Kwok-Wai; Chan, Matthew T V; Wang, Huating; Lee, Tin L; Yu, Jun; Wong, Nathalie; Yip, Kevin Y; To, Ka-Fai; Cheng, Alfred S L.

Afiliación

Tsang DP; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wu WK; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kang W; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lee YY; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wu F; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yu Z; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Xiong L; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chan AW; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Tong JH; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yang W; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Li MS; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lau SS; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Li X; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lee SD; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yang Y; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lai PB; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yu DY; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Xu G; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lo KW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chan MT; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wang H; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lee TL; Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yu J; Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wong N; Disease Model Research Laboratory, Aging Research Center and World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Yip KY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
To KF; Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Cheng AS; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong SAR, China.

J Pathol ; 238(5): 651-64, 2016 Apr.

Article en En | MEDLINE | ID: mdl-26800240

Asunto(s)

Carcinoma Hepatocelular/metabolismo; Silenciador del Gen; Neoplasias Hepáticas/metabolismo; MicroARNs/metabolismo; FN-kappa B/metabolismo; Factor de Transcripción YY1/metabolismo; Animales; Apoptosis; Sitios de Unión; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patología; Carcinoma Hepatocelular/virología; Línea Celular Tumoral; Proliferación Celular; Metilación de ADN; Proteína Potenciadora del Homólogo Zeste 2; Regulación Neoplásica de la Expresión Génica; Histonas/metabolismo; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Neoplasias Hepáticas/virología; Lisina; Metilación; Ratones Desnudos; Ratones Transgénicos; MicroARNs/genética; Complejo Represivo Polycomb 2/genética; Complejo Represivo Polycomb 2/metabolismo; Regiones Promotoras Genéticas; Interferencia de ARN; Transducción de Señal; Factores de Tiempo; Transactivadores/genética; Transactivadores/metabolismo; Transfección; Carga Tumoral; Regulación hacia Arriba; Proteínas Reguladoras y Accesorias Virales; Factor de Transcripción YY1/genética

Palabras clave

ChIP-seq; DNA methylation; EZH2; histone modification; liver cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: FN-kappa B / Carcinoma Hepatocelular / Silenciador del Gen / MicroARNs / Factor de Transcripción YY1 / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Idioma: En Revista: J Pathol Año: 2016 Tipo del documento: Article País de afiliación: China

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