Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV.
Curr HIV/AIDS Rep
; 13(1): 38-43, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26830285
ABSTRACT
The use of advanced tissue-imaging methodologies has greatly facilitated the study of molecular mechanisms and cellular interactions in humans and animal models of disease. Particularly, in HIV research, there is an ever-increasing demand for a comprehensive analysis of immune cell dynamics at tissue level stemming from the need to advance our understanding of those interactions that regulate the generation of adaptive antigen-specific immune responses. The latter is critical for the development of vaccines to elicit broadly neutralizing antibodies as well as for the discovery of novel targets for immuno-therapies to strengthen the cytolytic arm of the immune system at local level. In this review, we focus on current and emerging imaging technologies, discuss their strengths and limitations, and examine how such technologies can inform the development of new treatments and vaccination strategies. We also present some perspective on the future of the technology development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Infecciones por VIH
/
Síndrome de Inmunodeficiencia Adquirida del Simio
/
Microscopía Confocal
/
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
/
Tomografía de Emisión de Positrones
Límite:
Animals
/
Humans
Idioma:
En
Revista:
AIDS Rep
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos