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Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer.
Zheng, Lu; Li, Da; Zhou, Yi-Ming; Yang, Hui; Cheng, Di; Ma, Xiao-Xin.
Afiliación
  • Zheng L; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. zhenglu1980@yeah.net.
  • Li D; Department of Obstetrics and Gynecology, Central Hospital of Shenyang Medical College, Shenyang, 110024, China. zhenglu1980@yeah.net.
  • Zhou YM; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. leeda@ymail.com.
  • Yang H; Department of Medicine, Brigham and Women's Hospital, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, 02115, USA. yzhou22@partners.org.
  • Cheng D; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. 80719538@qq.com.
  • Ma XX; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. dicheng1987@yeah.net.
BMC Cancer ; 16: 93, 2016 Feb 12.
Article en En | MEDLINE | ID: mdl-26873694
BACKGROUND: The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown. METHODS: RAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well-differentiated endometrial cancer tissue, and 35 cases of poorly-differentiated endometrial cancer tissue. Regression analysis was used to examine the relationship between RAGE and microvessel density. The knockdown of RAGE was achieved using a small interfering RNA in HEC-1A endometrial cancer cells. A xenografted tumour model was used to evaluate RAGE-mediated microvascular formation and proliferation of endometrial cancer cells. RESULTS: It was shown that (i) RAGE expression gradually increased in normal endometrium, well-differentiated endometrial cancer, and poorly-differentiated endometrial cancer, respectively; (ii) a positive correlation existed between RAGE and microvessel density in human endometrial cancer samples; (iii) RAGE knockdown was effective in decreasing microvessel formation in xenografted tumour models; and (iv) RAGE knockdown can significantly inhibit the proliferation of endometrial cancer cells in vivo. CONCLUSIONS: These results indicate that RAGE may be a potential trigger in microvascular formation and proliferation in the development of endometrial cancer.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Proliferación Celular / Microvasos / Receptor para Productos Finales de Glicación Avanzada Límite: Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Proliferación Celular / Microvasos / Receptor para Productos Finales de Glicación Avanzada Límite: Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China