Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors.

Seip, Kotryna; Fleten, Karianne G; Barkovskaya, Anna; Nygaard, Vigdis; Haugen, Mads H; Engesæter, Birgit Ø; Mælandsmo, Gunhild M; Prasmickaite, Lina

Seip, Kotryna; Fleten, Karianne G; Barkovskaya, Anna; Nygaard, Vigdis; Haugen, Mads H; Engesæter, Birgit Ø; Mælandsmo, Gunhild M; Prasmickaite, Lina.

Afiliación

Seip K; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Fleten KG; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Barkovskaya A; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Nygaard V; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Haugen MH; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Engesæter BØ; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Mælandsmo GM; Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Prasmickaite L; K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Oncotarget ; 7(15): 19997-20015, 2016 Apr 12.

Article en En | MEDLINE | ID: mdl-26918352

Asunto(s)

Fibroblastos/patología; Melanoma/patología; Mesodermo/patología; Fosfatidilinositol 3-Quinasas/metabolismo; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores; Serina-Treonina Quinasas TOR/metabolismo; Animales; Apoptosis; Proliferación Celular; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Humanos; Melanoma/tratamiento farmacológico; Melanoma/metabolismo; Mesodermo/efectos de los fármacos; Mesodermo/metabolismo; Ratones Desnudos; Transducción de Señal/efectos de los fármacos; Células del Estroma/efectos de los fármacos; Células del Estroma/metabolismo; Células del Estroma/patología; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

BRAF inhibitor; fibroblasts; melanoma; phenotype switch; resistance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Serina-Treonina Quinasas TOR / Fibroblastos / Melanoma / Mesodermo Límite: Animals / Humans Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: Noruega

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