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CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Ng, Caroline L; Siciliano, Giulia; Lee, Marcus C S; de Almeida, Mariana J; Corey, Victoria C; Bopp, Selina E; Bertuccini, Lucia; Wittlin, Sergio; Kasdin, Rachel G; Le Bihan, Amélie; Clozel, Martine; Winzeler, Elizabeth A; Alano, Pietro; Fidock, David A.
Afiliación
  • Ng CL; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
  • Siciliano G; Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • Lee MC; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
  • de Almeida MJ; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
  • Corey VC; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
  • Bopp SE; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
  • Bertuccini L; Dipartimento Tecnologie e Salute, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • Wittlin S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
  • Kasdin RG; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
  • Le Bihan A; Department of Drug Discovery, Actelion Pharmaceuticals Ltd., CH-4123 Allschwil, Switzerland.
  • Clozel M; Department of Drug Discovery, Actelion Pharmaceuticals Ltd., CH-4123 Allschwil, Switzerland.
  • Winzeler EA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
  • Alano P; Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • Fidock DA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.
Mol Microbiol ; 101(3): 381-93, 2016 08.
Article en En | MEDLINE | ID: mdl-27073104
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperazinas / Plasmodium falciparum / Acrilamidas / Proteínas Asociadas a Resistencia a Múltiples Medicamentos / Artemisininas / Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas / Antimaláricos Límite: Humans Idioma: En Revista: Mol Microbiol Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperazinas / Plasmodium falciparum / Acrilamidas / Proteínas Asociadas a Resistencia a Múltiples Medicamentos / Artemisininas / Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas / Antimaláricos Límite: Humans Idioma: En Revista: Mol Microbiol Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos