The potential impacts of formyl peptide receptor 1 in inflammatory diseases.
Front Biosci (Elite Ed)
; 8(3): 436-49, 2016 06 01.
Article
en En
| MEDLINE
| ID: mdl-27100350
ABSTRACT
Neutrophils play a critical role in acute and chronic inflammatory diseases. N-formyl peptides, which originate from bacterial peptides or mitochondrial proteins bind with a high binding affinity to formyl peptide receptor 1 (FPR1). N-formyl peptide-FPR1 is involved in the pathogenesis of sterile and infectious inflammatory processes and causes phagocytosis of pathogens or injured cells by neutrophils. Excessive activation of neutrophils by binding of N-formyl peptides is associated with tissue injury requiring drugs that block FPR1-dependent signaling. Here, we review the roles of FPR1 as a critical regulator of inflammatory processes and its involvement in pathological conditions.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Formil Péptido
/
Inflamación
/
Neutrófilos
Idioma:
En
Revista:
Front Biosci (Elite Ed)
Asunto de la revista:
BIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Taiwán