Comparative Functional Alanine Positional Scanning of the &#945;-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.

Todorovic, Aleksandar; Ericson, Mark D; Palusak, Ryan D; Sorensen, Nicholas B; Wood, Michael S; Xiang, Zhimin; Haskell-Luevano, Carrie

Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.

Todorovic, Aleksandar; Ericson, Mark D; Palusak, Ryan D; Sorensen, Nicholas B; Wood, Michael S; Xiang, Zhimin; Haskell-Luevano, Carrie.

Afiliación

Todorovic A; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.
Ericson MD; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Palusak RD; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.
Sorensen NB; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.
Wood MS; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.
Xiang Z; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.
Haskell-Luevano C; Department of Medicinal Chemistry, University of Florida , Gainesville, Florida 32610, United States.

ACS Chem Neurosci ; 7(7): 984-94, 2016 07 20.

Article en En | MEDLINE | ID: mdl-27135265

Asunto(s)

Alanina/metabolismo; Proteínas del Ojo/metabolismo; Hormonas Estimuladoras de los Melanocitos/farmacología; Melanocitos/efectos de los fármacos; Proteínas del Tejido Nervioso/metabolismo; Receptores de Melanocortina/metabolismo; Animales; Células HEK293; Humanos; Ratones; Oligopéptidos/química; Oligopéptidos/farmacología; Procesamiento Proteico-Postraduccional/efectos de los fármacos; Receptores de Melanocortina/química; Relación Estructura-Actividad; Transfección; alfa-MSH/análogos & derivados; alfa-MSH/química; alfa-MSH/farmacología; beta-Galactosidasa/genética; beta-Galactosidasa/metabolismo

Palabras clave

GPCR; Melanotropin; NDP-MSH; alanine positional scan; obesity; α-MSH

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hormonas Estimuladoras de los Melanocitos / Receptores de Melanocortina / Alanina / Proteínas del Ojo / Melanocitos / Proteínas del Tejido Nervioso Límite: Animals / Humans Idioma: En Revista: ACS Chem Neurosci Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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