NF-&#954;B and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.

Austin, David C; Strand, Douglas W; Love, Harold L; Franco, Omar E; Grabowska, Magdalena M; Miller, Nicole L; Hameed, Omar; Clark, Peter E; Matusik, Robert J; Jin, Ren J; Hayward, Simon W

NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.

Austin, David C; Strand, Douglas W; Love, Harold L; Franco, Omar E; Grabowska, Magdalena M; Miller, Nicole L; Hameed, Omar; Clark, Peter E; Matusik, Robert J; Jin, Ren J; Hayward, Simon W.

Afiliación

Austin DC; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee.
Strand DW; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Love HL; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Franco OE; Department of Surgery, NorthShore University HealthSystem Research Institute, Evanston, Illinois.
Grabowska MM; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Miller NL; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Hameed O; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee.
Clark PE; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Matusik RJ; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Jin RJ; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee.
Hayward SW; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

Prostate ; 76(11): 1004-18, 2016 08.

Article en En | MEDLINE | ID: mdl-27197599

Asunto(s)

3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa/genética; Inhibidores de 5-alfa-Reductasa/uso terapéutico; Resistencia a Medicamentos; FN-kappa B/fisiología; Hiperplasia Prostática/tratamiento farmacológico; Receptores Androgénicos/fisiología; 3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa/fisiología; Animales; Apoptosis; Expresión Génica; Técnicas de Silenciamiento del Gen; Humanos; Isoenzimas/genética; Isoenzimas/fisiología; Síntomas del Sistema Urinario Inferior/patología; Masculino; Proteínas de la Membrana/genética; Proteínas de la Membrana/fisiología; Ratones; Ratones Desnudos; FN-kappa B/antagonistas & inhibidores; Orquiectomía; Próstata/patología; Hiperplasia Prostática/patología; Hiperplasia Prostática/cirugía; Neoplasias de la Próstata Resistentes a la Castración; Testosterona/biosíntesis; Insuficiencia del Tratamiento; Regulación hacia Arriba

Palabras clave

BPH; androgen receptor; androgen receptor variant 7; inflammation; p65

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hiperplasia Prostática / 3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa / Resistencia a Medicamentos / Receptores Androgénicos / FN-kappa B / Inhibidores de 5-alfa-Reductasa Límite: Animals / Humans / Male Idioma: En Revista: Prostate Año: 2016 Tipo del documento: Article

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