Construction of Large-Volume Tissue Mimics with 3D Functional Vascular Networks.
PLoS One
; 11(5): e0156529, 2016.
Article
en En
| MEDLINE
| ID: mdl-27228079
ABSTRACT
We used indirect stereolithography (SL) to form inner-layered fluidic networks in a porous scaffold by introducing a hydrogel barrier on the luminal surface, then seeded the networks separately with human umbilical vein endothelial cells and human lung fibroblasts to form a tissue mimic containing vascular networks. The artificial vascular networks provided channels for oxygen transport, thus reducing the hypoxic volume and preventing cell death. The endothelium of the vascular networks significantly retarded the occlusion of channels during whole-blood circulation. The tissue mimics have the potential to be used as an in vitro platform to examine the physiologic and pathologic phenomena through vascular architecture.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasos Sanguíneos
/
Ingeniería de Tejidos
/
Materiales Biomiméticos
/
Células Endoteliales de la Vena Umbilical Humana
/
Modelos Cardiovasculares
Límite:
Animals
/
Humans
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos