The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.

Matsunaga, Yasutaka; Adachi, Yasushi; Sasaki, Yasushi; Koide, Hideyuki; Motoya, Masayo; Nosho, Katsuhiko; Takagi, Hideyasu; Yamamoto, Hiroyuki; Sasaki, Shigeru; Arimura, Yoshiaki; Tokino, Takashi; Carbone, David P; Imai, Kohzoh; Shinomura, Yasuhisa

Matsunaga, Yasutaka; Adachi, Yasushi; Sasaki, Yasushi; Koide, Hideyuki; Motoya, Masayo; Nosho, Katsuhiko; Takagi, Hideyasu; Yamamoto, Hiroyuki; Sasaki, Shigeru; Arimura, Yoshiaki; Tokino, Takashi; Carbone, David P; Imai, Kohzoh; Shinomura, Yasuhisa.

Afiliación

Matsunaga Y; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Adachi Y; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Sasaki Y; Sapporo Shirakaba-Dai Hospital, Sapporo, Japan.
Koide H; Medical Genome Sciences, Research Institute of Frontier Medicine, Sapporo Medical University, Sapporo, Japan.
Motoya M; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Nosho K; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Takagi H; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Yamamoto H; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Sasaki S; Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Arimura Y; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Tokino T; Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Carbone DP; Medical Genome Sciences, Research Institute of Frontier Medicine, Sapporo Medical University, Sapporo, Japan.
Imai K; James Cancer Center, The Ohio State University Medical Center, Columbus, Ohio.
Shinomura Y; The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan.

Mol Carcinog ; 56(2): 515-526, 2017 02.

Article en En | MEDLINE | ID: mdl-27312358

Asunto(s)

Neoplasias Gastrointestinales/genética; Neoplasias Gastrointestinales/patología; Tracto Gastrointestinal/patología; Mutación; Proteínas Proto-Oncogénicas p21(ras)/genética; Receptor IGF Tipo 1/metabolismo; Animales; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Neoplasias Gastrointestinales/tratamiento farmacológico; Neoplasias Gastrointestinales/metabolismo; Tracto Gastrointestinal/efectos de los fármacos; Tracto Gastrointestinal/metabolismo; Genes ras; Humanos; Ratones; Terapia Molecular Dirigida; Invasividad Neoplásica/genética; Invasividad Neoplásica/patología; Invasividad Neoplásica/prevención & control; Podofilotoxina/análogos & derivados; Podofilotoxina/farmacología; Receptor IGF Tipo 1/antagonistas & inhibidores; Receptor IGF Tipo 1/genética; Transducción de Señal/efectos de los fármacos; Regulación hacia Arriba

Palabras clave

K-RAS mutation; colorectal cancer; decoy; insulin-like growth factor-1 receptor (IGF-1R); pancreatic cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Receptor IGF Tipo 1 / Tracto Gastrointestinal / Neoplasias Gastrointestinales / Mutación Límite: Animals / Humans Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Japón

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