Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.
BMC Genomics
; 17 Suppl 3: 436, 2016 06 29.
Article
en En
| MEDLINE
| ID: mdl-27357110
ABSTRACT
BACKGROUND:
Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF).METHODS:
In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets.RESULTS:
We identified 12 SNPs associated with increased prolactin levels in both biological fluids.CONCLUSIONS:
Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Prolactina
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Polimorfismo de Nucleótido Simple
/
Estudio de Asociación del Genoma Completo
Tipo de estudio:
Risk_factors_studies
/
Systematic_reviews
Límite:
Adult
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Aged
/
Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
BMC Genomics
Asunto de la revista:
GENETICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos