No Evidence of Reactivation of Hepatitis B Virus Among Patients Treated With Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection.

Sulkowski, Mark S; Chuang, Wan-Long; Kao, Jia-Horng; Yang, Jenny C; Gao, Bing; Brainard, Diana M; Han, Kwang-Hyub; Gane, Edward

Sulkowski, Mark S; Chuang, Wan-Long; Kao, Jia-Horng; Yang, Jenny C; Gao, Bing; Brainard, Diana M; Han, Kwang-Hyub; Gane, Edward.

Afiliación

Sulkowski MS; Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chuang WL; Kaohsiung Medical University Hospital.
Kao JH; National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Yang JC; Gilead Sciences, Foster City, California.
Gao B; Gilead Sciences, Foster City, California.
Brainard DM; Gilead Sciences, Foster City, California.
Han KH; Yonsei University College of Medicine, Seoul, South Korea.
Gane E; New Zealand Liver Transplant Unit, Auckland City Hospital.

Clin Infect Dis ; 63(9): 1202-1204, 2016 11 01.

Article en En | MEDLINE | ID: mdl-27486112

ABSTRACT

ABSTRACT

Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.

Asunto(s)

Antivirales/uso terapéutico; Bencimidazoles/uso terapéutico; Fluorenos/uso terapéutico; Virus de la Hepatitis B/efectos de los fármacos; Hepatitis B/virología; Hepatitis C/tratamiento farmacológico; Sofosbuvir/uso terapéutico; Activación Viral/efectos de los fármacos; Adulto; Anciano; Coinfección; Quimioterapia Combinada; Femenino; Hepatitis B/complicaciones; Hepatitis C/complicaciones; Humanos; Masculino; Persona de Mediana Edad

Palabras clave

ALT flare; HBV reactivation; HCV/HBV coinfection

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Activación Viral / Bencimidazoles / Virus de la Hepatitis B / Hepatitis C / Fluorenos / Sofosbuvir / Hepatitis B Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article

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