The Impact of N-terminal Acetylation of &#945;-Synuclein on Phospholipid Membrane Binding and Fibril Structure.

Iyer, Aditya; Roeters, Steven J; Schilderink, Nathalie; Hommersom, Bob; Heeren, Ron M A; Woutersen, Sander; Claessens, Mireille M A E; Subramaniam, Vinod

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure.

Iyer, Aditya; Roeters, Steven J; Schilderink, Nathalie; Hommersom, Bob; Heeren, Ron M A; Woutersen, Sander; Claessens, Mireille M A E; Subramaniam, Vinod.

Afiliación

Iyer A; From the Nanoscale Biophysics Group, FOM Institute AMOLF, Amsterdam, the Nanobiophysics Group, MESA+ Institute for Nanotechnology, University of Twente, Enschede.
Roeters SJ; the Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam.
Schilderink N; the Nanobiophysics Group, MESA+ Institute for Nanotechnology, University of Twente, Enschede.
Hommersom B; the BioImaging MS Group, FOM Institute AMOLF, Amsterdam, The Netherlands.
Heeren RM; the BioImaging MS Group, FOM Institute AMOLF, Amsterdam, The Netherlands, the M4I, The Maastricht MultiModal Molecular Imaging Institute, University of Maastricht, and.
Woutersen S; the Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, s.woutersen@uva.nl.
Claessens MM; the Nanobiophysics Group, MESA+ Institute for Nanotechnology, University of Twente, Enschede, m.m.a.e.claessens@utwente.nl.
Subramaniam V; From the Nanoscale Biophysics Group, FOM Institute AMOLF, Amsterdam, the Nanobiophysics Group, MESA+ Institute for Nanotechnology, University of Twente, Enschede, the Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands v.subramaniam@vu.nl.

J Biol Chem ; 291(40): 21110-21122, 2016 Sep 30.

Article en En | MEDLINE | ID: mdl-27531743

Asunto(s)

Membranas Artificiales; Fosfolípidos/química; Agregado de Proteínas; alfa-Sinucleína/química; Acetilación; Humanos; Fosfolípidos/metabolismo; Espectrofotometría Infrarroja; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo

Palabras clave

amyloid; circular dichroism (CD); lipid-protein interaction; post-translational modification (PTM); protein conformation; protein self-assembly

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfolípidos / Alfa-Sinucleína / Agregado de Proteínas / Membranas Artificiales Límite: Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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