A<sub>2A</sub>R Binding Kinetics in the Ligand Depletion Regime.

McNeely, Patrick M; Naranjo, Andrea N; Forsten-Williams, Kimberly; Robinson, Anne Skaja

A_2AR Binding Kinetics in the Ligand Depletion Regime.

McNeely, Patrick M; Naranjo, Andrea N; Forsten-Williams, Kimberly; Robinson, Anne Skaja.

Afiliación

McNeely PM; 1 Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.
Naranjo AN; 1 Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.
Forsten-Williams K; 3 Department of Biomedical Engineering, Duquesne University, Pittsburgh, PA, USA.
Robinson AS; 1 Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.

SLAS Discov ; 22(2): 166-175, 2017 02.

Article en En | MEDLINE | ID: mdl-27577981

Asunto(s)

Ligandos; Transporte de Proteínas/genética; Receptor de Adenosina A2A/química; Sitios de Unión; Unión Competitiva; Polarización de Fluorescencia; Humanos; Cinética; Unión Proteica; Receptor de Adenosina A2A/metabolismo

Palabras clave

G proteincoupled receptor; binding affinity; efficacy; residence time

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transporte de Proteínas / Receptor de Adenosina A2A / Ligandos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: SLAS Discov Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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