DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.

Xia, Li-Liang; Tang, Ya-Bin; Song, Fei-Fei; Xu, Ling; Ji, Ping; Wang, Shu-Jun; Zhu, Ji-Min; Zhang, Yong; Zhao, Guo-Ping; Wang, Ying; Liu, Tao-Tao

Xia, Li-Liang; Tang, Ya-Bin; Song, Fei-Fei; Xu, Ling; Ji, Ping; Wang, Shu-Jun; Zhu, Ji-Min; Zhang, Yong; Zhao, Guo-Ping; Wang, Ying; Liu, Tao-Tao.

Afiliación

Xia LL; State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Tang YB; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.
Song FF; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xu L; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ji P; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wang SJ; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhu JM; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhang Y; Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhao GP; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wang Y; State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Liu TT; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.

Oncotarget ; 7(42): 68623-68637, 2016 Oct 18.

Article en En | MEDLINE | ID: mdl-27612427

Asunto(s)

Fluorouracilo/farmacología; Pirofosfatasas/metabolismo; Neoplasias Gástricas/tratamiento farmacológico; Regulación hacia Arriba/efectos de los fármacos; Subfamilia B de Transportador de Casetes de Unión a ATP/genética; Subfamilia B de Transportador de Casetes de Unión a ATP/metabolismo; Animales; Antimetabolitos Antineoplásicos/farmacología; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/genética; Metilación de ADN/efectos de los fármacos; Nucleótidos de Desoxicitosina/metabolismo; Humanos; Ratones Endogámicos BALB C; Ratones Desnudos; Pirofosfatasas/genética; Interferencia de ARN; Neoplasias Gástricas/genética; Neoplasias Gástricas/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto/métodos

Palabras clave

5-methyl-dCTP; chemoresistance to 5-fluorouracil; dCTP pyrophosphatase 1; methylation; multidrug resistance 1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirofosfatasas / Neoplasias Gástricas / Regulación hacia Arriba / Fluorouracilo Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: China

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