The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.

Marusak, Charles; Bayles, Ian; Ma, Jun; Gooyit, Major; Gao, Ming; Chang, Mayland; Bedogni, Barbara

Marusak, Charles; Bayles, Ian; Ma, Jun; Gooyit, Major; Gao, Ming; Chang, Mayland; Bedogni, Barbara.

Afiliación

Marusak C; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Bayles I; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Ma J; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
Gooyit M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, United States.
Gao M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, United States.
Chang M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, United States.
Bedogni B; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States. Electronic address: bxb278@case.edu.

Pharmacol Res ; 113(Pt A): 515-520, 2016 11.

Article en En | MEDLINE | ID: mdl-27687955

Asunto(s)

Arginina/análogos & derivados; Proliferación Celular/efectos de los fármacos; Metaloproteinasa 14 de la Matriz/metabolismo; Metaloproteinasa 2 de la Matriz/metabolismo; Inhibidores de la Metaloproteinasa de la Matriz/farmacología; Melanoma/tratamiento farmacológico; Metástasis de la Neoplasia/tratamiento farmacológico; Sulfuros/farmacología; Sulfonas/farmacología; Animales; Arginina/farmacología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Humanos; Masculino; Melanoma/metabolismo; Ratones; Ratones Endogámicos NOD; Ratones SCID

Palabras clave

Growth; Invasion; MMP2; MT1-MMP; Melanoma; Metastasis; Migration; ND-322

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arginina / Sulfuros / Sulfonas / Metaloproteinasa 2 de la Matriz / Proliferación Celular / Metaloproteinasa 14 de la Matriz / Inhibidores de la Metaloproteinasa de la Matriz / Melanoma / Metástasis de la Neoplasia Límite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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