Your browser doesn't support javascript.
loading
Release of experimental retinal vein occlusions by direct intraluminal injection of ocriplasmin.
de Smet, Marc D; Stassen, Jean Marie; Meenink, Thijs C M; Janssens, Tom; Vanheukelom, Valérie; Naus, Gerrit J L; Beelen, Maarten J; Jonckx, Bart.
Afiliación
  • de Smet MD; MicroInvasive Ocular Surgery Center (MIOS sa), Lausanne, Switzerland.
  • Stassen JM; Preceyes nv, Eindhoven, The Netherlands.
  • Meenink TC; Crystapharm bvba, Lubbeek, Belgium.
  • Janssens T; Preceyes nv, Eindhoven, The Netherlands.
  • Vanheukelom V; Thrombogenics nv, Leuven, Belgium.
  • Naus GJ; Thrombogenics nv, Leuven, Belgium.
  • Beelen MJ; Preceyes nv, Eindhoven, The Netherlands.
  • Jonckx B; Preceyes nv, Eindhoven, The Netherlands.
Br J Ophthalmol ; 100(12): 1742-1746, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27688592
PURPOSE: Retinal vein occlusions (RVO) are a major cause of vision loss in people aged 50 years and older. Current therapeutic options limit the consequences of RVO but do not eliminate the cause. Cannulation of the involved vessel and removal of the clot may provide a more permanent solution with a less demanding follow-up. However, cannulation of smaller retinal veins remains challenging. This paper explores the use of ocriplasmin (recombinant plasmin without its kringles) to clear RVO, using a robotic micromanipulator. METHODS: Branch RVO were induced in a porcine model with rose bengal followed by 532 nm endolaser to the superior venous branch of the optic nerve. The vein was cannulated proximal to the occlusion or beyond the first branching vessel from the obstruction. The vein was infused with a physiologic citric acid buffer solution (CAM) or CAM/ocriplasmin. The time of cannulation, number of attempts, and the ability to release the thrombus were recorded. RESULTS: Cannulation and infusion was possible in all the cases. The use of a micromanipulator allowed for a consistent cannulation of the retinal vein and positional stability allowed the vein to remain cannulated for up to 20 min. In none of the attempts (5/5) with CAM did the thrombus dissolve, despite repeat infusion/relaxation cycles. In 7/7 injections of CAM/ocriplasmin near to the point of obstruction, the clot started to dissolve within a few minutes of injection. An infusion, attempted beyond the first venous branch point proximal to the clot, was unsuccessful in 2/3 attempts. CONCLUSIONS: Ocriplasmin is effective in resolving RVO if injected close to the site of occlusion with the use of a micromanipulator.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Oclusión de la Vena Retiniana / Fibrinolisina Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Br J Ophthalmol Año: 2016 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Oclusión de la Vena Retiniana / Fibrinolisina Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Br J Ophthalmol Año: 2016 Tipo del documento: Article País de afiliación: Suiza