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Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
Furness, Sebastian George Barton; Liang, Yi-Lynn; Nowell, Cameron James; Halls, Michelle Louise; Wookey, Peter John; Dal Maso, Emma; Inoue, Asuka; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick Michael.
Afiliación
  • Furness SGB; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia. Electronic address: sebastian.furness@monash.edu.
  • Liang YL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Nowell CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Halls ML; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Wookey PJ; Department of Medicine, Austin Health, University of Melbourne, Austin Campus, Heidelberg, VIC 3084, Australia.
  • Dal Maso E; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-0065, Japan; Japan Science and Technology Agency (JST), Precursory Research for Embryonic Sciences and Technology (PRESTO), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
  • Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.
  • Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia. Electronic address: patrick.sexton@monash.edu.
Cell ; 167(3): 739-749.e11, 2016 Oct 20.
Article en En | MEDLINE | ID: mdl-27720449
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de Calcitonina / Proteínas de Unión al GTP / Guanosina Trifosfato Límite: Animals / Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de Calcitonina / Proteínas de Unión al GTP / Guanosina Trifosfato Límite: Animals / Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article