In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration.

Mathison, Megumi; Singh, Vivek P; Chiuchiolo, Maria J; Sanagasetti, Deepthi; Mao, Yun; Patel, Vivekkumar B; Yang, Jianchang; Kaminsky, Stephen M; Crystal, Ronald G; Rosengart, Todd K

Mathison, Megumi; Singh, Vivek P; Chiuchiolo, Maria J; Sanagasetti, Deepthi; Mao, Yun; Patel, Vivekkumar B; Yang, Jianchang; Kaminsky, Stephen M; Crystal, Ronald G; Rosengart, Todd K.

Afiliación

Mathison M; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Singh VP; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Chiuchiolo MJ; Department of Genetic Medicine, Weill Cornell Medical College, New York, NY.
Sanagasetti D; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Mao Y; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Patel VB; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Yang J; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
Kaminsky SM; Department of Genetic Medicine, Weill Cornell Medical College, New York, NY.
Crystal RG; Department of Genetic Medicine, Weill Cornell Medical College, New York, NY.
Rosengart TK; Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, Tex. Electronic address: todd.rosengart@bcm.edu.

J Thorac Cardiovasc Surg ; 153(2): 329-339.e3, 2017 02.

Article en En | MEDLINE | ID: mdl-27773576

Asunto(s)

Técnicas de Reprogramación Celular/métodos; Infarto del Miocardio/patología; Miocitos Cardíacos/patología; Regeneración; Adenoviridae; Animales; Transdiferenciación Celular; Modelos Animales de Enfermedad; Fibroblastos/metabolismo; Fibroblastos/patología; Técnicas de Transferencia de Gen; Vectores Genéticos; Masculino; Infarto del Miocardio/tratamiento farmacológico; Infarto del Miocardio/metabolismo; Miocitos Cardíacos/metabolismo; Ratas; Ratas Sprague-Dawley; Factor A de Crecimiento Endotelial Vascular/farmacología

Palabras clave

adenoviral vector; gene therapy; in situ cardiac reprogramming

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regeneración / Miocitos Cardíacos / Técnicas de Reprogramación Celular / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Thorac Cardiovasc Surg Año: 2017 Tipo del documento: Article

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