Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.

Gao, Rong; Ji, Mu-Huo; Gao, Da-Peng; Yang, Run-Hua; Zhang, Shao-Gang; Yang, Jian-Jun; Shen, Jin-Chun

Gao, Rong; Ji, Mu-Huo; Gao, Da-Peng; Yang, Run-Hua; Zhang, Shao-Gang; Yang, Jian-Jun; Shen, Jin-Chun.

Afiliación

Gao R; Department of Emergency and Intensive Care Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Ji MH; Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.
Gao DP; Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Yang RH; Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.
Zhang SG; Department of Emergency and Intensive Care Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Yang JJ; Department of Anesthesiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, 210014, China.
Shen JC; Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China. yjyangjj@126.com.

Inflammation ; 40(2): 387-400, 2017 Apr.

Article en En | MEDLINE | ID: mdl-27913953

Asunto(s)

Encefalitis/patología; Hipocampo/metabolismo; Hipocampo/fisiopatología; Neurregulina-1/metabolismo; Receptor ErbB-4/metabolismo; Encefalopatía Asociada a la Sepsis/fisiopatología; Animales; Disfunción Cognitiva/tratamiento farmacológico; Disfunción Cognitiva/etiología; Modelos Animales de Enfermedad; Regulación hacia Abajo; Inhibidores Enzimáticos/farmacología; Inhibidores Enzimáticos/uso terapéutico; Ritmo Gamma; Hipocampo/química; Interneuronas/metabolismo; Ratones; Parvalbúminas; Quinazolinas/farmacología; Quinazolinas/uso terapéutico; Receptor ErbB-4/antagonistas & inhibidores; Transducción de Señal/efectos de los fármacos; Tirfostinos/farmacología; Tirfostinos/uso terapéutico

Palabras clave

ErbB4; cognitive impairment; neuregulin 1; neuroinflammation; sepsis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neurregulina-1 / Encefalitis / Encefalopatía Asociada a la Sepsis / Receptor ErbB-4 / Hipocampo Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Inflammation Año: 2017 Tipo del documento: Article País de afiliación: China

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