Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists.

Mohsen, Amal M Y; Mandour, Yasmine M; Sarukhanyan, Edita; Breitinger, Ulrike; Villmann, Carmen; Banoub, Maha M; Breitinger, Hans-Georg; Dandekar, Thomas; Holzgrabe, Ulrike; Sotriffer, Christoph; Jensen, Anders A; Zlotos, Darius P

Mohsen, Amal M Y; Mandour, Yasmine M; Sarukhanyan, Edita; Breitinger, Ulrike; Villmann, Carmen; Banoub, Maha M; Breitinger, Hans-Georg; Dandekar, Thomas; Holzgrabe, Ulrike; Sotriffer, Christoph; Jensen, Anders A; Zlotos, Darius P.

Afiliación

Mohsen AM; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.
Mandour YM; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.
Breitinger U; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.
Villmann C; Institute of Clinical Neurobiology, University of Würzburg , 97078 Würzburg, Germany.
Banoub MM; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.
Breitinger HG; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.
Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , DK-2100 Copenhagen, Denmark.
Zlotos DP; Faculty of Pharmacy and Biotechnology, The German University in Cairo , New Cairo City, 11835 Cairo, Egypt.

J Nat Prod ; 79(12): 2997-3005, 2016 Dec 23.

Article en En | MEDLINE | ID: mdl-27966945

Asunto(s)

Éteres/síntesis química; Oximas/farmacología; Receptores de Glicina/antagonistas & inhibidores; Estricnina; Animales; Sitios de Unión; Unión Competitiva; Cristalografía por Rayos X; Éteres/química; Éteres/farmacología; Glicina/análisis; Glicina/metabolismo; Humanos; Concentración 50 Inhibidora; Ligandos; Conformación Molecular; Estructura Molecular; Oximas/química; Relación Estructura-Actividad; Estricnina/análogos & derivados; Estricnina/síntesis química; Estricnina/química; Estricnina/farmacología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oximas / Estricnina / Receptores de Glicina / Éteres Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article País de afiliación: Egipto

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