Microwave-Assisted Synthesis of Antimicrobial Peptides.
Methods Mol Biol
; 1548: 51-59, 2017.
Article
en En
| MEDLINE
| ID: mdl-28013496
ABSTRACT
Antimicrobial peptides (AMPs) are emerging as one of the unsurpassed therapeutic tools to treat various devastating diseases that are affecting millions of lives. Conventional synthesis of peptides requires longer times, and hence automated microwave technology could be regarded as an alternative implement which offers advantages like less reaction times and higher yields. In this sense, we herein describe a methodology to prepare AMPs through solid-phase peptide synthesis under microwave conditions. We have used LL37 as an example to discuss the synthetic protocol including the difficulties involved in the preparation of so-called long and difficult peptides and also remedial procedures to overcome these obstacles.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Catiónicos Antimicrobianos
/
Técnicas de Química Sintética
/
Antiinfecciosos
/
Microondas
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Sudáfrica