STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells.
Exp Cell Res
; 351(1): 51-58, 2017 02 01.
Article
en En
| MEDLINE
| ID: mdl-28034671
ABSTRACT
NADPH oxidase (NOX) generates reactive oxygen species (ROS) and has been suggested to mediate cell proliferation in some cancers. Here, we show that an increase in the expression of NOX5 long form (NOX5-L) is critical for tumor progression in breast tumor tissues. Immunostaining of clinical samples indicated that NOX5 was overexpressed in 41.1% of breast ductal carcinoma samples. NOX5-L depletion consistently suppressed cell proliferation, invasion, and migration in vitro. Antibody-mediated neutralization of NOX5-L attenuated tumor progression in a mouse xenograft model. Promoter analysis revealed that NOX5-L expression is regulated by STAT5A in breast cancer cells. Based on our novel findings, we suggest that inhibition of NOX5-L may be a promising therapeutic strategy that exerts anti-cancer effects via the modulation of ROS-mediated cell signaling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
NADPH Oxidasas
/
Proteínas Supresoras de Tumor
/
Proliferación Celular
/
Factor de Transcripción STAT5
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Neoplasias Mamarias Experimentales
/
Proteínas de la Membrana
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Exp Cell Res
Año:
2017
Tipo del documento:
Article