Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.

Fujita, Naonobu; Huang, Wilson; Lin, Tzu-Han; Groulx, Jean-Francois; Jean, Steve; Nguyen, Jen; Kuchitsu, Yoshihiko; Koyama-Honda, Ikuko; Mizushima, Noboru; Fukuda, Mitsunori; Kiger, Amy A

Fujita, Naonobu; Huang, Wilson; Lin, Tzu-Han; Groulx, Jean-Francois; Jean, Steve; Nguyen, Jen; Kuchitsu, Yoshihiko; Koyama-Honda, Ikuko; Mizushima, Noboru; Fukuda, Mitsunori; Kiger, Amy A.

Afiliación

Fujita N; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Huang W; Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Lin TH; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Groulx JF; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Jean S; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Nguyen J; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Kuchitsu Y; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Koyama-Honda I; Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Mizushima N; Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Fukuda M; Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kiger AA; Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.

Elife ; 62017 01 07.

Article en En | MEDLINE | ID: mdl-28063257

Asunto(s)

Autofagia/genética; Drosophila melanogaster/genética; Regulación del Desarrollo de la Expresión Génica; Morfogénesis/genética; Músculos/metabolismo; Proteína de Unión al GTP rab2/metabolismo; Animales; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Drosophila melanogaster/crecimiento & desarrollo; Drosophila melanogaster/metabolismo; Perfilación de la Expresión Génica; Lisosomas/metabolismo; Fusión de Membrana; Fagosomas/metabolismo; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Transporte de Proteínas; Proteínas Qa-SNARE/genética; Proteínas Qa-SNARE/metabolismo; Proteínas R-SNARE/genética; Proteínas R-SNARE/metabolismo; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Proteínas SNARE/genética; Proteínas SNARE/metabolismo; Transducción de Señal; Proteínas de Unión al GTP rab/genética; Proteínas de Unión al GTP rab/metabolismo; Proteína de Unión al GTP rab2/antagonistas & inhibidores; Proteína de Unión al GTP rab2/genética; Proteínas de Unión a GTP rab7

Palabras clave

Drosophila metamorphosis; Rab GTPase; T-tubule; autophagosome-lysosome fusion; autophagy; cell biology; developmental biology; muscle fiber; stem cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Regulación del Desarrollo de la Expresión Génica / Proteína de Unión al GTP rab2 / Drosophila melanogaster / Morfogénesis / Músculos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Elife Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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