Omecamtiv Mecarbil Enhances the Duty Ratio of Human ß-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle.

Swenson, Anja M; Tang, Wanjian; Blair, Cheavar A; Fetrow, Christopher M; Unrath, William C; Previs, Michael J; Campbell, Kenneth S; Yengo, Christopher M

Swenson, Anja M; Tang, Wanjian; Blair, Cheavar A; Fetrow, Christopher M; Unrath, William C; Previs, Michael J; Campbell, Kenneth S; Yengo, Christopher M.

Afiliación

Swenson AM; From the Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.
Tang W; From the Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.
Blair CA; the Department of Physiology and Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky 40536-0298, and.
Fetrow CM; From the Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.
Unrath WC; From the Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.
Previs MJ; the Department of Molecular Physiology and Biophysics, Cardiovascular Research Institute, University of Vermont, Burlington, Vermont 05405.
Campbell KS; the Department of Physiology and Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky 40536-0298, and.
Yengo CM; From the Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, cmy11@psu.edu.

J Biol Chem ; 292(9): 3768-3778, 2017 03 03.

Article en En | MEDLINE | ID: mdl-28082673

Asunto(s)

Calcio/química; Miocardio/metabolismo; Urea/análogos & derivados; Miosinas Ventriculares/química; Actinas/química; Actomiosina/química; Adenosina Difosfato/química; Animales; Relación Dosis-Respuesta a Droga; Humanos; Cinética; Espectrometría de Masas; Ratones; Miosinas/química; Dominios Proteicos; Proteínas Recombinantes/química; Estrés Mecánico; Urea/química

Palabras clave

actin; calcium sensitivity; cardiac muscle; contractile protein; molecular motor; myosin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Urea / Calcio / Miosinas Ventriculares / Miocardio Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

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