Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.

Bhushan, Bharat; Chavan, Hemantkumar; Borude, Prachi; Xie, Yuchao; Du, Kuo; McGill, Mitchell R; Lebofsky, Margitta; Jaeschke, Hartmut; Krishnamurthy, Partha; Apte, Udayan

Bhushan, Bharat; Chavan, Hemantkumar; Borude, Prachi; Xie, Yuchao; Du, Kuo; McGill, Mitchell R; Lebofsky, Margitta; Jaeschke, Hartmut; Krishnamurthy, Partha; Apte, Udayan.

Afiliación

Bhushan B; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Chavan H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Borude P; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Xie Y; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Du K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
McGill MR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Lebofsky M; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Krishnamurthy P; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
Apte U; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 uapte@kumc.edu.

Toxicol Sci ; 155(2): 363-378, 2017 02.

Article en En | MEDLINE | ID: mdl-28123000

Asunto(s)

Acetaminofén/toxicidad; Analgésicos no Narcóticos/toxicidad; Enfermedad Hepática Inducida por Sustancias y Drogas/enzimología; Sobredosis de Droga/enzimología; Receptores ErbB/fisiología; Hepatocitos/efectos de los fármacos; Regeneración Hepática; Acetaminofén/metabolismo; Analgésicos no Narcóticos/metabolismo; Animales; Receptores ErbB/antagonistas & inhibidores; Glutatión/metabolismo; Hepatocitos/enzimología; Fallo Hepático Agudo/inducido químicamente; Fallo Hepático Agudo/enzimología; Ratones; Mitocondrias Hepáticas/efectos de los fármacos; Mitocondrias Hepáticas/enzimología; Estrés Oxidativo; Unión Proteica

Palabras clave

Cyclin D1; Hepatotoxicity; N-acetylcysteine; hepatocyte proliferation.; mitochondrial dysfunction

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Analgésicos no Narcóticos / Hepatocitos / Enfermedad Hepática Inducida por Sustancias y Drogas / Sobredosis de Droga / Receptores ErbB / Regeneración Hepática / Acetaminofén Límite: Animals Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google