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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Qi, Wei; Zhao, Kehao; Gu, Justin; Huang, Ying; Wang, Youzhen; Zhang, Hailong; Zhang, Man; Zhang, Jeff; Yu, Zhengtian; Li, Ling; Teng, Lin; Chuai, Shannon; Zhang, Chao; Zhao, Mengxi; Chan, HoMan; Chen, Zijun; Fang, Douglas; Fei, Qi; Feng, Leying; Feng, Lijian; Gao, Yuan; Ge, Hui; Ge, Xinjian; Li, Guobin; Lingel, Andreas; Lin, Ying; Liu, Yueqin; Luo, Fangjun; Shi, Minlong; Wang, Long; Wang, Zhaofu; Yu, Yanyan; Zeng, Jue; Zeng, Chenhui; Zhang, Lijun; Zhang, Qiong; Zhou, Shaolian; Oyang, Counde; Atadja, Peter; Li, En.
Afiliación
  • Qi W; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhao K; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Gu J; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Huang Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Wang Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang H; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang M; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang J; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Yu Z; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Li L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Teng L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Chuai S; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang C; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhao M; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Chan H; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Chen Z; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Fang D; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Fei Q; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Feng L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Feng L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Gao Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Ge H; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Ge X; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Li G; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Lingel A; Novartis Institutes for BioMedical Research, Emeryville, California, USA.
  • Lin Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Liu Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Luo F; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Shi M; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Wang L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Wang Z; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Yu Y; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zeng J; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zeng C; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang L; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhang Q; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Zhou S; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Oyang C; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Atadja P; Novartis Institutes for BioMedical Research, Shanghai, China.
  • Li E; Novartis Institutes for BioMedical Research, Shanghai, China.
Nat Chem Biol ; 13(4): 381-388, 2017 04.
Article en En | MEDLINE | ID: mdl-28135235
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonas / Triazoles / Histonas / Complejo Represivo Polycomb 2 / Lisina / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonas / Triazoles / Histonas / Complejo Represivo Polycomb 2 / Lisina / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China