Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.
Nat Immunol
; 18(4): 412-421, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28166218
ABSTRACT
Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromatina
/
Diferenciación Celular
/
Linfocitos T Reguladores
/
Factor 1 Regulador del Interferón
/
Factores de Transcripción con Cremalleras de Leucina de Carácter Básico
Límite:
Animals
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos