Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.

Alam, Md Morshedul; Okazaki, Keito; Nguyen, Linh Thi Thao; Ota, Nao; Kitamura, Hiroshi; Murakami, Shohei; Shima, Hiroki; Igarashi, Kazuhiko; Sekine, Hiroki; Motohashi, Hozumi

Alam, Md Morshedul; Okazaki, Keito; Nguyen, Linh Thi Thao; Ota, Nao; Kitamura, Hiroshi; Murakami, Shohei; Shima, Hiroki; Igarashi, Kazuhiko; Sekine, Hiroki; Motohashi, Hozumi.

Afiliación

Alam MM; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Okazaki K; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Nguyen LTT; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Ota N; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Kitamura H; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Murakami S; From the Department of Gene Expression Regulation, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575.
Shima H; the Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, and.
Igarashi K; CREST, AMED, Sendai, Miyagi 980-8575, Japan.
Sekine H; the Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, and.
Motohashi H; CREST, AMED, Sendai, Miyagi 980-8575, Japan.

J Biol Chem ; 292(18): 7519-7530, 2017 05 05.

Article en En | MEDLINE | ID: mdl-28314773

Asunto(s)

Dexametasona/farmacología; Histonas/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Receptores de Glucocorticoides/metabolismo; Transducción de Señal/efectos de los fármacos; Acetilación/efectos de los fármacos; Animales; Histonas/genética; Proteína 1 Asociada A ECH Tipo Kelch/genética; Proteína 1 Asociada A ECH Tipo Kelch/metabolismo; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones; Ratones Noqueados; Factor 2 Relacionado con NF-E2/genética; Estrés Oxidativo/efectos de los fármacos; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Receptores de Glucocorticoides/genética

Palabras clave

Nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2); electrophile; gene transcription; glucocorticoid receptor; histone acetylation; oxidative stress

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dexametasona / Histonas / Transducción de Señal / Receptores de Glucocorticoides / Factor 2 Relacionado con NF-E2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

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