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α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production.
Paillusson, Sébastien; Gomez-Suaga, Patricia; Stoica, Radu; Little, Daniel; Gissen, Paul; Devine, Michael J; Noble, Wendy; Hanger, Diane P; Miller, Christopher C J.
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  • Paillusson S; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK.
  • Gomez-Suaga P; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK.
  • Stoica R; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK.
  • Little D; MRC Laboratory of Molecular Cell Biology, University College London, London, UK.
  • Gissen P; MRC Laboratory of Molecular Cell Biology, University College London, London, UK.
  • Devine MJ; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Noble W; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK.
  • Hanger DP; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK.
  • Miller CCJ; Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe road, London, SE5 9RX, UK. chris.miller@kcl.ac.uk.
Acta Neuropathol ; 134(1): 129-149, 2017 07.
Article en En | MEDLINE | ID: mdl-28337542
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Calcio / Proteínas de Transporte Vesicular / Alfa-Sinucleína / Homeostasis / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Calcio / Proteínas de Transporte Vesicular / Alfa-Sinucleína / Homeostasis / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Acta Neuropathol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido