Validated UHPLC-MS/MS assay for quantitative determination of etoposide, gemcitabine, vinorelbine and their metabolites in patients with lung cancer.

Gong, Xiaobin; Yang, Le; Zhang, Feng; Liang, Youtian; Gao, Shouhong; Liu, Ke; Chen, Wansheng

Gong, Xiaobin; Yang, Le; Zhang, Feng; Liang, Youtian; Gao, Shouhong; Liu, Ke; Chen, Wansheng.

Afiliación

Gong X; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Yang L; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Zhang F; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Liang Y; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Gao S; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Liu K; Department of Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Chen W; Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.

Biomed Chromatogr ; 31(11)2017 Nov.

Article en En | MEDLINE | ID: mdl-28409868

Asunto(s)

Antineoplásicos/sangre; Cromatografía Líquida de Alta Presión/métodos; Desoxicitidina/análogos & derivados; Etopósido/sangre; Neoplasias Pulmonares; Espectrometría de Masas en Tándem/métodos; Vinblastina/análogos & derivados; Anciano; Antineoplásicos/metabolismo; Antineoplásicos/uso terapéutico; Estudios de Cohortes; Desoxicitidina/sangre; Desoxicitidina/metabolismo; Desoxicitidina/uso terapéutico; Etopósido/metabolismo; Etopósido/uso terapéutico; Humanos; Modelos Lineales; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Persona de Mediana Edad; Reproducibilidad de los Resultados; Sensibilidad y Especificidad; Vinblastina/sangre; Vinblastina/metabolismo; Vinblastina/uso terapéutico; Vinorelbina; Gemcitabina

Palabras clave

UHPLC-MS/MS; etoposide; gemcitabine; human plasma; metabolite; vinorelbine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vinblastina / Cromatografía Líquida de Alta Presión / Desoxicitidina / Etopósido / Espectrometría de Masas en Tándem / Neoplasias Pulmonares / Antineoplásicos Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Biomed Chromatogr Año: 2017 Tipo del documento: Article

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