Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.

Morreale, Francesca E; Bortoluzzi, Alessio; Chaugule, Viduth K; Arkinson, Connor; Walden, Helen; Ciulli, Alessio

Morreale, Francesca E; Bortoluzzi, Alessio; Chaugule, Viduth K; Arkinson, Connor; Walden, Helen; Ciulli, Alessio.

Afiliación

Morreale FE; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
Bortoluzzi A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
Chaugule VK; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
Arkinson C; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
Walden H; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.
Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dundee DD1 5EH, United Kingdom.

J Med Chem ; 60(9): 4093-4098, 2017 05 11.

Article en En | MEDLINE | ID: mdl-28437106

Asunto(s)

Anemia de Fanconi/enzimología; Enzimas Ubiquitina-Conjugadoras/metabolismo; Regulación Alostérica; Humanos; Ubiquitinación

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enzimas Ubiquitina-Conjugadoras / Anemia de Fanconi Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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